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致命的感染率上升:迫切需要新的课程

2019-09-12/ 深泽百科网/ 查看: 214/ 评论: 10

摘要在全球范围内,随着越来越多的细菌对抗生素产生抗药性,感染死亡的人数也在增加。迫切需要新课程。生物化学

在全球范围内,随着越来越多的细菌对抗生素产生抗药性,感染死亡的人数也在增加。迫切需要新课程。生物化学教授纳撒尼尔·马丁(Nathaniel Martin)的研究小组正在开发一种有希望的抗性抑制剂。9月13日的就职演说。

这些数字令人担忧:全球约有70万名患者死于20世纪70年代和80年代可能接受抗生素治疗的感染。但是越来越多的细菌菌株变得越来越耐药。原因:抗生素的质量和使用不正确以及这些药物的新类别太少。

如果没有认真的投资和创新,到2050年抗生素耐药性每年可能造成多达1000万人死亡。“

Nathaniel Martin,莱顿大学生物化学教授

通过他的莱顿研究小组,马丁正在研究一种有希望的解决方案,它可能能够对抗细菌的抗性机制。研究人员开发出一类新的分子抑制剂,可阻断侵袭性抗性酶。实验室研究表明,当与这些新抑制剂结合使用时,常规抗生素能够杀死耐药细菌。马丁最近申请了这项创新方法的专利。随后将对这些抑制剂进行进一步研究。'激动人心的时刻!'?马丁说。

毒性较小

马丁还在使用有机化学方法对传统抗生素进行结构修饰,使其更安全,更有效。他的研究小组已设法减少某类抗生素多粘菌素的毒性。马丁:'多粘菌素是非常重要的抗生素,因为它们是医生在治疗某些多重耐药性感染时仍然拥有的少数几种选择。


不再是制药行业的优先事项

尽管抗生素起着至关重要的作用,但只有三家大型制药公司正在开发新的抗生素。绝大多数抗生素是在20世纪40年代中期到20世纪70年代初期之间发现的。在此期间,发现许多天然抗生素 - 通常是在土壤中发现的抗菌物质 - 相对容易变成药物。随着抗生素的开发变得更加困难,制药业的焦点开始转向其他疾病,如癌症。


需要激励措施

鉴于对传统抗生素的抗药性越来越强,新抗生素的短缺会产生重大影响。马丁呼吁各国政府向制药公司提供激励措施,以开发新的抗生素。他认为莱顿生物科技园的合作机会很大。“它是欧洲顶级科技园之一,为希望创建创新衍生公司的大学研究人员提供了一个独特的生态系统。”

抗生素也用于手术和化疗

马丁强调,抗生素不仅是治愈细菌感染的必要条件,也是现代医疗机构的基础。患者在主要医疗程序之前接受抗生素治疗 - 例如新的髋关节,器官移植或化疗 - 以对抗可能的感染。

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